SOLOMED 500MG INJ
SOLOMED 500MG INJECTION ONLINE AT BEST PRICE IN PAKISTAN
GENERIC: Methylprednisolone Sodium Succinate 500mg
MANUFACTURER: Pharmasol (Pvt) Ltd
QUANTITY:
Single vial for injection
INDICATION
Solomed 500mg Inj is a high-dose intravenous corticosteroid indicated for pulse therapy in severe autoimmune and inflammatory conditions including acute exacerbations of multiple sclerosis, lupus nephritis, acute organ transplant rejection, severe dermatomyositis, and other conditions requiring rapid, intensive immunosuppression.
MECHANISM OF ACTION
At the 500mg pulse dose, methylprednisolone achieves supraphysiological plasma concentrations producing profound immunosuppression through both genomic and non-genomic mechanisms. Rapid non-genomic effects include direct membrane stabilization and inhibition of immune cell signaling cascades, while genomic effects suppress transcription of pro-inflammatory cytokines. This dual-phase action is particularly effective in rapidly arresting acute inflammatory cascades in autoimmune diseases and allograft rejection.
DOSAGE AND ADMINISTRATION
ā¢Ā Ā Ā Ā Ā Pulse therapy: 500mg by slow IV infusion over 30 to 60 minutes once daily for 3 days
ā¢Ā Ā Ā Ā Ā Multiple sclerosis relapse: 500mg to 1g IV once daily for 3 to 5 days
ā¢Ā Ā Ā Ā Ā Always administered in a hospital or clinical setting with cardiac monitoring
ā¢Ā Ā Ā Ā Ā Dosage and duration prescribed by a specialist physician
SIDE EFFECTS
Common:
ā¢Ā Ā Ā Ā Ā Flushing, metallic taste, and palpitations during infusion
ā¢Ā Ā Ā Ā Ā Hyperglycemia
ā¢Ā Ā Ā Ā Ā Elevated blood pressure and fluid retention
ā¢Ā Ā Ā Ā Ā Insomnia and mood disturbances
Less common:
ā¢Ā Ā Ā Ā Ā Cardiac arrhythmias including bradycardia (administer slowly; monitor ECG)
ā¢Ā Ā Ā Ā Ā Anaphylaxis (rare)
ā¢Ā Ā Ā Ā Ā Serious infections due to immunosuppression
ā¢Ā Ā Ā Ā Ā Avascular necrosis of bone with repeated pulse courses
NOT RECOMMENDED IN
ā¢Ā Ā Ā Ā Ā Systemic fungal infections
ā¢Ā Ā Ā Ā Ā Known hypersensitivity to methylprednisolone
ā¢Ā Ā Ā Ā Ā Rapid intravenous bolus administration at 500mg doses (must infuse slowly)
ā¢Ā Ā Ā Ā Ā Active severe infection without antibiotic coverage
DRUG INTERACTIONS
NSAIDs increase GI ulceration risk. CYP3A4 inhibitors increase methylprednisolone levels. Cyclosporine and methylprednisolone mutually inhibit each other's CYP3A4 metabolism; monitor both levels. Live vaccines are contraindicated. Antidiabetic agents need dose adjustment during high-dose steroid therapy.
STORAGE INSTRUCTIONS
Store unconstituted vials below 25Ā°C away from light. Use reconstituted solution immediately. Do not freeze. Keep out of reach of children.
WHERE TO BUY
You can buy Solomed 500mg Inj online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Solomed 500mg Inj price in pakistan and learn about Solomed 500mg Inj uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Solomed 500mg Inj uses, pricing, and order placement.
Ā
Product Information
Product Information
Shipping & Returns
Shipping & Returns
SOLOMED 500MG INJ
SOLOMED 500MG INJ
SOLOMED 500MG INJECTION ONLINE AT BEST PRICE IN PAKISTAN
GENERIC: Methylprednisolone Sodium Succinate 500mg
MANUFACTURER: Pharmasol (Pvt) Ltd
QUANTITY:
Single vial for injection
INDICATION
Solomed 500mg Inj is a high-dose intravenous corticosteroid indicated for pulse therapy in severe autoimmune and inflammatory conditions including acute exacerbations of multiple sclerosis, lupus nephritis, acute organ transplant rejection, severe dermatomyositis, and other conditions requiring rapid, intensive immunosuppression.
MECHANISM OF ACTION
At the 500mg pulse dose, methylprednisolone achieves supraphysiological plasma concentrations producing profound immunosuppression through both genomic and non-genomic mechanisms. Rapid non-genomic effects include direct membrane stabilization and inhibition of immune cell signaling cascades, while genomic effects suppress transcription of pro-inflammatory cytokines. This dual-phase action is particularly effective in rapidly arresting acute inflammatory cascades in autoimmune diseases and allograft rejection.
DOSAGE AND ADMINISTRATION
ā¢Ā Ā Ā Ā Ā Pulse therapy: 500mg by slow IV infusion over 30 to 60 minutes once daily for 3 days
ā¢Ā Ā Ā Ā Ā Multiple sclerosis relapse: 500mg to 1g IV once daily for 3 to 5 days
ā¢Ā Ā Ā Ā Ā Always administered in a hospital or clinical setting with cardiac monitoring
ā¢Ā Ā Ā Ā Ā Dosage and duration prescribed by a specialist physician
SIDE EFFECTS
Common:
ā¢Ā Ā Ā Ā Ā Flushing, metallic taste, and palpitations during infusion
ā¢Ā Ā Ā Ā Ā Hyperglycemia
ā¢Ā Ā Ā Ā Ā Elevated blood pressure and fluid retention
ā¢Ā Ā Ā Ā Ā Insomnia and mood disturbances
Less common:
ā¢Ā Ā Ā Ā Ā Cardiac arrhythmias including bradycardia (administer slowly; monitor ECG)
ā¢Ā Ā Ā Ā Ā Anaphylaxis (rare)
ā¢Ā Ā Ā Ā Ā Serious infections due to immunosuppression
ā¢Ā Ā Ā Ā Ā Avascular necrosis of bone with repeated pulse courses
NOT RECOMMENDED IN
ā¢Ā Ā Ā Ā Ā Systemic fungal infections
ā¢Ā Ā Ā Ā Ā Known hypersensitivity to methylprednisolone
ā¢Ā Ā Ā Ā Ā Rapid intravenous bolus administration at 500mg doses (must infuse slowly)
ā¢Ā Ā Ā Ā Ā Active severe infection without antibiotic coverage
DRUG INTERACTIONS
NSAIDs increase GI ulceration risk. CYP3A4 inhibitors increase methylprednisolone levels. Cyclosporine and methylprednisolone mutually inhibit each other's CYP3A4 metabolism; monitor both levels. Live vaccines are contraindicated. Antidiabetic agents need dose adjustment during high-dose steroid therapy.
STORAGE INSTRUCTIONS
Store unconstituted vials below 25Ā°C away from light. Use reconstituted solution immediately. Do not freeze. Keep out of reach of children.
WHERE TO BUY
You can buy Solomed 500mg Inj online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Solomed 500mg Inj price in pakistan and learn about Solomed 500mg Inj uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Solomed 500mg Inj uses, pricing, and order placement.
Ā
Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
SOLOMED 500MG INJECTION ONLINE AT BEST PRICE IN PAKISTAN
GENERIC: Methylprednisolone Sodium Succinate 500mg
MANUFACTURER: Pharmasol (Pvt) Ltd
QUANTITY:
Single vial for injection
INDICATION
Solomed 500mg Inj is a high-dose intravenous corticosteroid indicated for pulse therapy in severe autoimmune and inflammatory conditions including acute exacerbations of multiple sclerosis, lupus nephritis, acute organ transplant rejection, severe dermatomyositis, and other conditions requiring rapid, intensive immunosuppression.
MECHANISM OF ACTION
At the 500mg pulse dose, methylprednisolone achieves supraphysiological plasma concentrations producing profound immunosuppression through both genomic and non-genomic mechanisms. Rapid non-genomic effects include direct membrane stabilization and inhibition of immune cell signaling cascades, while genomic effects suppress transcription of pro-inflammatory cytokines. This dual-phase action is particularly effective in rapidly arresting acute inflammatory cascades in autoimmune diseases and allograft rejection.
DOSAGE AND ADMINISTRATION
ā¢Ā Ā Ā Ā Ā Pulse therapy: 500mg by slow IV infusion over 30 to 60 minutes once daily for 3 days
ā¢Ā Ā Ā Ā Ā Multiple sclerosis relapse: 500mg to 1g IV once daily for 3 to 5 days
ā¢Ā Ā Ā Ā Ā Always administered in a hospital or clinical setting with cardiac monitoring
ā¢Ā Ā Ā Ā Ā Dosage and duration prescribed by a specialist physician
SIDE EFFECTS
Common:
ā¢Ā Ā Ā Ā Ā Flushing, metallic taste, and palpitations during infusion
ā¢Ā Ā Ā Ā Ā Hyperglycemia
ā¢Ā Ā Ā Ā Ā Elevated blood pressure and fluid retention
ā¢Ā Ā Ā Ā Ā Insomnia and mood disturbances
Less common:
ā¢Ā Ā Ā Ā Ā Cardiac arrhythmias including bradycardia (administer slowly; monitor ECG)
ā¢Ā Ā Ā Ā Ā Anaphylaxis (rare)
ā¢Ā Ā Ā Ā Ā Serious infections due to immunosuppression
ā¢Ā Ā Ā Ā Ā Avascular necrosis of bone with repeated pulse courses
NOT RECOMMENDED IN
ā¢Ā Ā Ā Ā Ā Systemic fungal infections
ā¢Ā Ā Ā Ā Ā Known hypersensitivity to methylprednisolone
ā¢Ā Ā Ā Ā Ā Rapid intravenous bolus administration at 500mg doses (must infuse slowly)
ā¢Ā Ā Ā Ā Ā Active severe infection without antibiotic coverage
DRUG INTERACTIONS
NSAIDs increase GI ulceration risk. CYP3A4 inhibitors increase methylprednisolone levels. Cyclosporine and methylprednisolone mutually inhibit each other's CYP3A4 metabolism; monitor both levels. Live vaccines are contraindicated. Antidiabetic agents need dose adjustment during high-dose steroid therapy.
STORAGE INSTRUCTIONS
Store unconstituted vials below 25Ā°C away from light. Use reconstituted solution immediately. Do not freeze. Keep out of reach of children.
WHERE TO BUY
You can buy Solomed 500mg Inj online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Solomed 500mg Inj price in pakistan and learn about Solomed 500mg Inj uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Solomed 500mg Inj uses, pricing, and order placement.
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