ONSET 4MG/5ML SUSP 25ML ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Ondansetron 4mg/5ml

MANUFACTURER: Pharmedic

QUANTITY

25ml oral suspension

INDICATION

Onset 4mg/5ml Suspension is a selective serotonin 5-HT3 receptor antagonist antiemetic indicated for the prevention and treatment of nausea and vomiting associated with chemotherapy, radiotherapy, and surgery in pediatric and adult patients. The liquid formulation provides accurate weight-based dosing for children and patients who cannot swallow tablets. Ondansetron is one of the most widely used antiemetics in clinical practice due to its effectiveness and favorable safety profile.

MECHANISM OF ACTION

Ondansetron selectively blocks serotonin 5-HT3 receptors located both peripherally on vagal nerve terminals in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema. During chemotherapy, radiation, or surgery, damaged cells release serotonin, which stimulates 5-HT3 receptors and triggers the vomiting reflex. By blocking these receptors, ondansetron interrupts the emetic pathway and prevents both nausea and vomiting.

DOSAGE AND ADMINISTRATION

●     Children 6 months to 11 years: 0.15mg/kg body weight up to 3 times daily, starting 30 minutes before chemotherapy

●     Children 4 to 11 years (post-operative): 4mg orally before surgery

●     Adults: 8mg (10ml) twice daily for chemotherapy-induced nausea

●     Shake well before measuring each dose with the provided device

●     May be taken with or without food

●     First dose should be given 30 minutes before the emetogenic trigger

SIDE EFFECTS

Common:

●     Headache, which is the most commonly reported adverse effect

●     Constipation

●     Drowsiness and fatigue

●     Dizziness

Less common:

●     QT prolongation, particularly in patients with pre-existing cardiac conditions or electrolyte imbalances

●     Serotonin syndrome when combined with other serotonergic drugs

●     Transient elevation of liver enzymes

●     Allergic reactions including rash (rare)

NOT RECOMMENDED IN

●     Known hypersensitivity to ondansetron or any 5-HT3 antagonist

●     Concurrent use with apomorphine due to risk of severe hypotension

●     Patients with congenital long QT syndrome

●     Severe hepatic impairment (maximum dose 8mg daily)

DRUG INTERACTIONS

Concurrent use with apomorphine is contraindicated due to profound hypotension. Serotonergic drugs (SSRIs, SNRIs, tramadol, fentanyl) may increase serotonin syndrome risk. CYP3A4 inducers (rifampicin, phenytoin, carbamazepine) may decrease ondansetron effectiveness. Ondansetron may reduce the analgesic effect of tramadol.

STORAGE INSTRUCTIONS

Store below 25 degrees Celsius. Protect from light. Do not freeze. Keep bottle tightly closed. Shake well before use. Keep out of reach of children.

WHERE TO BUY

Dawa Healthcare Pharmacy at dawahealthcare.biz stocks Onset 4mg/5ml Suspension for nausea and vomiting control. View the Onset 4mg/5ml Sus 25ml price in Pakistan and explore Onset 4mg/5ml Sus 25ml uses for chemotherapy nausea, post-surgical vomiting, and pediatric antiemetic treatment on our product page. Dawa Healthcare branches across Karachi maintain antiemetic medications. Same-day delivery covers all Karachi areas, and nationwide courier delivers across Pakistan. WhatsApp ordering at each branch offers pharmacist support.